We are student team T.E.S.T. which represents the Netherlands during the 2019 SensUs competition. Our interdisciplinary team consists of 13 students from Eindhoven University of Technology including second- and third-year bachelor and first-year master students from the following majors: Medical Sciences and Technology, Chemical Engineering and Chemistry, Biomedical Engineering and Computer Science. The challenge of SensUs 2019 is to develop a biosensor for the medicine Adalimumab, sold as Humira. This drug is used to fight rheumatoid arthritis. This is a chronic inflammatory disorder that is characterized by inflammation of the synovium of small joints, like the hands and feet, which leads to the destruction of articular cartilage and bone. The cause of this disorder is not well understood, but the overexpression of proinflammatory cytokines plays an important role. One cytokine that plays a key role is TNF-alfa, Adalimumab binds specifically to this cytokine. The competition will take place in September 2019 and everyone is welcome to visit. For more information about the SensUs competition, click here.
The first meeting of our team.
We picked bioluminescence as our method to base our sensor on.
We started working in the lab of Chemical Biology on the Tu/e campus. We have practised making proteins and will continue working on this until the end of next week. Afterwards, we are hoping to start by performing our own experiments.
Biorad is our first acquired sponsor.
The assay is working, now we will continue to optimize it!